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Rock Lab

Research Publications

Bosch B, Munsamy-Govender V, Sarathy J, Lilic M, Olinares PDB, Eckartt KA, Nalam P, Lang M, Simon M, Richter A, Rock JM, Campbell EA.
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas
Nature Microbiology, 2025.

Eckartt KA, Delbeau M, Munsamy-Govender V, DeJesus MA, Azadian ZA, Reddy AK, Chandanani J, Poulton NC, Quiñones-Garcia S, Bosch B, Landick R, Campbell EA, Rock JM.

Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis

Ju X, Li S, Froom R, Wang L, Lilic M, Campbell EA, Rock JM, Liu S.

Incomplete transcripts dominate the Mycobacterium tuberculosis transcriptome

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Poulton NC, DeJesus MA, Munsamy-Govender V, Roberts CG, Azadian ZA, Bosch B, Lin KM, Li S, Rock JM.

Beyond antibiotic resistance: the whiB7 transcription factor
coordinates an adaptive response to alanine starvation in mycobacteria

Cell Chem Biol, 2024.

Wong AI, Beites T, Planck KA, Li S, Poulton NC, Rhee K, Schnappinger D, Ehrt S, Rock JM. Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis.

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Poulton NC, Azadian ZA, DeJesus MA, Rock JM.

Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis.

Antimicrobial Agents and Chemotherapy, 2022.

d'Andrea FB, Poulton NC, Froom R, Tam K, Campbell EA, Rock JM.

The essential M. tuberculosis Clp protease is functionally asymmetric in vivo.

Science Advances, 2022.

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Li S, Poulton NC, Chang JS, Azadian ZA, DeJesus MA, Ruecker N, Zimmerman MD, Eckartt KA, Bosch B, Engelhart CA, Sullivan DF, Gengenbacher M, Dartois VA, Schnappinger D, Rock JM.

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis.

Nature Microbiology, 2022.

Bosch B, DeJesus MA, Poulton NC, Zhang W, Engelhart CA, Zaveri A, Lavalette S, Ruecker N, Trujillo C, Wallach JB, Li S, Ehrt S, Chait BT, Schnappinger D, Rock JM.

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.

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Collaborations

Delbeau M, Omollo EO, Froom R, Koh S, Mooney RA, Lilic M, Brewer JJ, Rock J, Darst SA, Campbell EA, Landick R.
Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol Cell, 2023.

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Theriault ME, Pisu D, Wilburn KM, Le-Bury G, Mcnamara C, Petrassi HM, Love M, Rock JM, VanderVen B, Russell DG.
Iron limitation in M. tuberculosis has broad impact on bacterial metabolism revealing alternative routes to novel therapeutics.
Communications Biology, 2022.

Babunovic GH, DeJesus MA, Bosch B, Chase MR, Barbier T, Dickey AK, Bryson BD, Rock JM, Fortune SM.
CRISPR interference reveals that all-trans-retinoic acid promotes macrophage control of Mycobacterium tuberculosis by limiting bacterial access to cholesterol and propionyl Coenzyme A.
mBio, 2022.

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Wetzel KS, Guerrero-Bustamante CA, Dedrick RM, Ko C, Freeman KG, Aull HG, Divens AM, Rock JM, Zack KM, Hatfull GM.
CRISPY-BRED and CRISPY-BRIP: Efficient bacteriophage engineering.
Scientific Reports, 2021.

Fay A, Czudnochowski N, Rock JM, Johnson JR, Krogan NJ, Rosenberg O, Glickman MS.
Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.
mBio, 2019.

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Landeta C, McPartland L, Tran NQ, Meehan BM, Zhang Y, Tanweer Z, Wakabayashi S, Rock J, Kim T, Balasubramanian D, Audette R, Toosky M, Pinkham J, Rubin EJ, Lory S, Pier G, Boyd D, Beckwith J.
Inhibition of Pseudomonas aeruginosa and Mycobacterium tuberculosis disulfide bond forming enzymes.
Molecular Microbiology, 2018.

Reviews & Book Chapters

Bosch B, DeJesus MA, Schnappinger D, Rock JM.
Weak links: Advancing target-based drug discovery by identifying the most vulnerable targets
Annals of the New York Academy of Sciences, 2024.

Poulton NC, Rock JM.
Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis. Frontiers in Cellular and Infection Microbiology, 2022.

Wong AI, Rock JM.
CRISPR Interference (CRISPRi) for Targeted Gene Silencing in Mycobacteria.
Methods in Molecular Biology, 2021.

Rock J.
Tuberculosis drug discovery in the CRISPR era.
PLoS Pathogens, 2019.

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Jeremy's Postdoc Publications

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Gerrick ER, Barbier T, Chase MR, Xu R, François J, Lin VH, Szucs MJ, Rock JM, Ahmad R, Tjaden B, Livny J, Fortune SM.
Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response.
Proceedings of the National Academy of Sciences USA, 2018.

Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM.
TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities. PLoS Pathogens, 2018.

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Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM.
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.
Nature Microbiology, 2017.

Warner DF, Rock JM, Fortune SM, Mizrahi V.
DNA Replication Fidelity in the Mycobacterium tuberculosis Complex.
Advances in Experimental Medicine and Biology, 2017.

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Rock JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R, Coscolla M, Gagneux S, Fortune SM, Lamers MH.
DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader.
Nature Genetics, 2015.

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