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Research Publications

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Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis

Andrew I. Wong, Tiago Beites, Kyle A. Planck, Shuqi Li, Nicholas C. Poulton, Kyu Rhee, Dirk Schnappinger, Sabine Ehrt, Jeremy M. Rock

bioRxiv 2022.

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Mutations in rv0678 confer low-level resistance to benzothiazinone DprE1 inhibitors in M. tuberculosis

Nicholas C. Poulton, Zachary A. Azadian, Michael A. DeJesus, Jeremy M. Rock

Antimicrobial Agents and Chemotherapy 2022. PMID: 35920665.

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The essential M. tuberculosis Clp protease is functionally asymmetric in vivo

Felipe B. d’Andrea*, Nicholas C. Poulton*, Ruby Froom, Kayan Tam, Elizabeth A. Campbell, Jeremy M. Rock

Science Advances 2022. PMID: 35507665. (*) co-first authors

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CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

Shuqi Li*, Nicholas C. Poulton*, Jesseon S. Chang, Zachary A. Azadian, Michael A. DeJesus, Nadine Ruecker, Matthew D. Zimmerman, Kathryn A. Eckartt, Barbara Bosch, Curtis A. Engelhart, Daniel F. Sullivan, Martin Gengenbacher, Véronique A. Dartois, Dirk Schnappinger, Jeremy M. Rock

Nature Microbiology 2022. PMID: 35637331. (*) co-first authors

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Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.

Barbara Bosch*, Michael A. DeJesus*, Nicholas C. Poulton, Wenzhu Zhang, Curtis A. Engelhart, Anisha Zaveri, Sophie Lavalette, Nadine Ruecker, Carolina Trujillo, Joshua B. Wallach, Shuqi Li, Sabine Ehrt, Brian T. Chait, Dirk Schnappinger†, Jeremy M. Rock†

Cell 2021. PMID: 34297925. (*) co-first authors; (†) co-corresponding authors

Colorful Notebooks

Collaborations

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Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.

Allison Fay, Nadine Czudnochowski, Jeremy M. Rock, Jeffrey R. Johnson, Nevan J. Krogan, Oren Rosenberg, Michael S. Glickman

mBio 2019. PMID: 31239378.

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Inhibition of Pseudomonas aeruginosa and Mycobacterium tuberculosis disulfide bond forming enzymes.

Cristina Landeta, Laura McPartland, Ngoc Q. Tran, Brian M. Meehan, Yifan Zhang, Zaidi Tanweer, Shoko Wakabayashi, Jeremy Rock, Taehyun Kim, Deepak Balasubramanian, Rebecca Audette, Melody Toosky, Jessica Pinkham, Eric J. Rubin, Stephen Lory, Gerald Pier, Dana Boyd, Jon Beckwith

Molecular Microbiology 2019. PMID: 30556355.

A pen on a pile of documents

Reviews & Book Chapters

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Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis

Nicholas C. Poulton and Jeremy M. Rock

Frontiers in Cellular and Infection Microbiology 2022. DOI: 10.3389/fcimb.2022.997283

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CRISPR Interference (CRISPRi) for Targeted Gene Silencing in Mycobacteria

Andrew I. Wong, Jeremy M. Rock

Mycobacteria Protocols. Methods in Molecular Biology, vol 2314. 2021. PMID: 34235662.

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Tuberculosis drug discovery in the CRISPR era.

Jeremy M. Rock

PLoS Pathogens 2019. PMID: 31536613.

Books On Shelf

Jeremy's Postdoc Publications

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Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response.

Elias R. Gerrick, Thibault Barbier, Michael R. Chase, Raylin Xu, Josie François, Vincent H. Lin, Matthew J. Szucs, Jeremy M. Rock, Rushdy Ahmad, Brian Tjaden, Jonathan Livny, and Sarah M. Fortune

Proceedings of the National Academy of Sciences 2018. PMID: 29871950.

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TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

Allison F. Carey, Jeremy M. Rock, Inna V. Krieger, Michael R. Chase, Marta Fernandez-Suarez, Sebastien Gagneux, James C. Sacchettini, Thomas R. Ioerger, Sarah M. Fortune

PLoS Pathogens 2018. PMID: 29505613.

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DNA Replication Fidelity in the Mycobacterium tuberculosis Complex.

​Digby F. Warner, Jeremy M. Rock, Sarah M. Fortune,
and Valerie Mizrahi

Advances in Experimental Medicine and Biology 2017. PMID: 29116639.

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